A study of temperature control in different designs of emergency drug transport bags

Thatcher, NicholasandDingley, JandWilliams, D(2019)A study of temperature control in different designs of emergency drug transport bags.Anaesthesia, 74 (7). pp. 868-874. ISSN 1365-2044

存档 Draft_of_wax_chamber_as_accepted_by_the_journal_Anaesthesia (1).zip- Accepted Version Available under LicenseCreative Commons Attribution Non-commercial. Download (2MB)

Abstract

We investigated whether low melting point phase-change waxes could be incorporated into emergency drug transport bags to attenuate the known temperature extremes their contents can be exposed to. We exposed two custom-made hollow-walled drug containers placed within a pair of drug transport bags to three day/night cycles including periods of direct radiant sunlight. The wall cavities of one contained air, whereas those of the other contained a paraffin wax (melting point of 44-46 °C) with a high latent heat of fusion (until fully melted, its temperature does not increase further). We collected 25,920 temperature datasets at six locations. We found that 97.8% and 84.7% of ampoule temperatures within the wax and air cavity containers, respectively, were within a target range of 15-40 °C over the study duration (Levene statistic W = 4279.1; Levene's test for equality of variance, p < 0.001). Ampoule temperatures in the wax cavity container only exceeded 40 °C for 1.7% of the time. Even when they did so, their temperature was attenuated to 40.3 °C, despite an ambient air temperature of > 40 °C for 6.4% of the time (peak 46.9 °C) and a bag surface temperature of > 40 °C for 17.2% of the time (peak 64.4 °C). In contrast, the ampoule temperature in the air cavity container exceeded 40 °C for 17.1% of the time (peak 54.1 °C). The latent heat of fusion of phase-change materials may be exploited in the design of drug transport bags to mitigate any temperature changes in the drugs stored within them.

Item Type:	Article
Additional Information:	"This is the peer reviewed version of the following article: "This is the peer reviewed version of the following article: Thatcher, N., Dingley, J. and Williams, D. A study of temperature control in different designs of emergency drug transport bags , which has been published in final form at 10.1111/anae.14665. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Uncontrolled Keywords:	drug storage; drug transport; emergency medical team; thermal stability.
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General)
Divisions:	Institutes and Academies > Wales Institute for Science & Art (WISA) > Academic Discipline: Architecture & Design
Depositing User:	10没有找到用户。
Date Deposited:	24 Feb 2021 09:30
Last Modified:	01 Feb 2023 16:16
URI:	https://repository.www.guaguababy.com/id/eprint/1598

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